SUBTYPES OF MATURE T AND NK CELL LYMPHOMAS ACCORDING TO 2016 WHO CLASSIFICATION. PRELIMINARY REPORT OF THE INTERNATIONAL PROSPECTIVE T‐CELL PROJECT 2.0

Introduction: Mature T and NK-cell lymphomas represent a heterogeneous group of lymphoid disorders (29 subtypes according to the 2016 WHO classification) arising from mature cells post-thymic origin with different morphological characteristics, phenotypes, clinical presentation. Following success Cell Project (TCP), which allowed analysis more than 1,500 cases peripheral T-Cell (PTCLs) collected prospectively in 18 Countries, 2018 TCP 2.0 was launched. Here we report global distribution PTCLs, registered so far based on locally established histological diagnosis. Methods: The TCP2.0 (ClinicalTrials.gov Identifier: NCT03964480) is prospective, international, observational study adapts changes made new classification. Results: Since beginning (October 2018), 648 patients newly diagnosed PTCL were by 75 active centers across 14 countries. Of these data, 594 have been validated centralized trial office. Overall, PTCL-NOS, Anaplastic large cell lymphoma (ALCL) ALK-negative, Angioimmunoblastic T-cell (AITL), most frequent subtypes, representing 31.3%, 18,9% 13,5% cases, respectively. As reported Table 1, PTCL-NOS represents subtype worldwide, whereas Adult leukemia/lymphoma Brazil, AITL ALCL ALK-negative Australia/India, ALK-positive North America Europe. Extranodal NK/T-cell lymphoma, nasal type relatively Brazil quite rare other Latin Countries. Finally, many sub-types less 5% all geographic areas. Conclusions: continues recruit very well, despite difficulties linked COVID-19 pandemic, may useful resource for prospective this lymphomas. research funded by: Associazione Angela Serra per la Ricerca sul Cancro Keywords: Aggressive non-Hodgkin Pathology Classification Lymphomas Conflicts interests pertinent abstract E. A. Hawkes Other remuneration: Takeda, Roche